Avascular osteonecrosis after treatment of SARS: a 3‐year longitudinal study
Identifieur interne : 002B74 ( Main/Exploration ); précédent : 002B73; suivant : 002B75Avascular osteonecrosis after treatment of SARS: a 3‐year longitudinal study
Auteurs : Hui Lv ; Sake J. De Vlas ; Wei Liu ; Tian-Bao Wang ; Zhao-Yang Cao ; Chun-Peng Li ; Wu-Chun Cao ; Jan Hendrik RichardusSource :
- Tropical Medicine & International Health [ 1360-2276 ] ; 2009.
Abstract
Url:
DOI: 10.1111/j.1365-3156.2008.02187.x
PubMed: NONE
PubMed Central: 7169846
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Avascular osteonecrosis after treatment of SARS: a 3‐year longitudinal study</title>
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<author><name sortKey="Wang, Tian Ao" sort="Wang, Tian Ao" uniqKey="Wang T" first="Tian-Bao" last="Wang">Tian-Bao Wang</name>
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<author><name sortKey="Cao, Zhao Ang" sort="Cao, Zhao Ang" uniqKey="Cao Z" first="Zhao-Yang" last="Cao">Zhao-Yang Cao</name>
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<author><name sortKey="Li, Chun Eng" sort="Li, Chun Eng" uniqKey="Li C" first="Chun-Peng" last="Li">Chun-Peng Li</name>
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<author><name sortKey="Cao, Wu Hun" sort="Cao, Wu Hun" uniqKey="Cao W" first="Wu-Chun" last="Cao">Wu-Chun Cao</name>
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<series><title level="j">Tropical Medicine & International Health</title>
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<front><div type="abstract" xml:lang="en"><title>Summary</title>
<p><bold>Objective </bold>
To investigate the relationship between avascular osteonecrosis (AVN) and corticosteroid treatment given to patients with severe acute respiratory syndrome (SARS).</p>
<p><bold>Methods </bold>
Longitudinal study of 71 former SARS patients (mainly health care workers) who had been treated with corticosteroids, with an observation time of 36 months. Magnetic resonance images (MRI) and X‐rays of hips, knees, shoulders, ankles and wrists were taken as part of the post‐SARS follow‐up assessments.</p>
<p><bold>Results </bold>
Thirty‐nine per cent developed AVN of the hips within 3–4 months after starting treatment. Two more cases of hip necrosis were seen after 1 year and another 11 cases of AVN were diagnosed after 3 years, one with hip necrosis and 10 with necrosis in other joints. In total, 58% of the cohort had developed AVN after 3 years of observation. The sole factor explaining AVN in the hip was the total dose of corticosteroids received.</p>
<p><bold>Conclusion </bold>
The use of corticosteroids in SARS has been debated; opinions conflict about whether the immediate benefits in terms of saving lives compensate for the adverse effects, including AVN.</p>
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<name sortKey="Cao, Zhao Ang" sort="Cao, Zhao Ang" uniqKey="Cao Z" first="Zhao-Yang" last="Cao">Zhao-Yang Cao</name>
<name sortKey="De Vlas, Sake J" sort="De Vlas, Sake J" uniqKey="De Vlas S" first="Sake J." last="De Vlas">Sake J. De Vlas</name>
<name sortKey="Li, Chun Eng" sort="Li, Chun Eng" uniqKey="Li C" first="Chun-Peng" last="Li">Chun-Peng Li</name>
<name sortKey="Liu, Wei" sort="Liu, Wei" uniqKey="Liu W" first="Wei" last="Liu">Wei Liu</name>
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<name sortKey="Richardus, Jan Hendrik" sort="Richardus, Jan Hendrik" uniqKey="Richardus J" first="Jan Hendrik" last="Richardus">Jan Hendrik Richardus</name>
<name sortKey="Wang, Tian Ao" sort="Wang, Tian Ao" uniqKey="Wang T" first="Tian-Bao" last="Wang">Tian-Bao Wang</name>
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